Fonts are tricky. Usually I just don't add them and let the reader use the fonts on the device. However, in some cases it can add something to the reading experience. Think about headers or example or what about a note (e.g. a letter) in the text. There it can add to it.
In some cases I change the body font, Caslon is very nice and is very usable for e-ink. For some people I change the body font for a font that is suitable for dyslexic. With those fonts they can read much more easily. I think that all readers should have a built-in font for dyslexic people anyway.
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