If you only want to remove the old tags and replace with new ones.
1. Select the eBooks you want to have the tag "Science Fiction." Or any tag(s) you want to use.
2. Open "Edit Metadata" for those eBooks.
3. Go to the box "Add Tags." Type in Science Fiction and any other tags you want.
4. Go to the box "Remove Tags." Do not type in the box. Click on the "Remove all" checkbox at the end of the row.
5. Click on "Ok" or "Apply."
It has been awhile since I have done this....so test with a small group before going whole-hog