6" inch (Cybook) felt slightly small to me, which is why I got an iLiad Book ed. (8"). I DO prefer the 8" screen size, but I DON'T like the extra weight.
Bigger is better for student/work reading, especially since so much content come in PDFs and you can't properly resize/reformat it. For recreational reading, I think smaller and lighter is more comfortable and is really all you need. It's also more portable.
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