Even when I read on Android, removing the line-height seems to default to whatever leading or line-height is built into the font itself, so I've never run into a problem with this. But, yes, I mostly read with a Kobo, which allows me to set the line-height for a font if I don't like the default spacing between lines. Works for me, and Kovid's super-duper --explode-book/--implode-book duo is fantastic!
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