I don't bother with frame-by-frame - I much prefer a more "authentic" reading experience. I read all my comics on a 12.9" iPad Pro, which renders them very close to their original size. Sometimes I have to turn it sideways to read two-page spreads, but even then, they are clear enough that I don't have to zoom.
For software, I use ComicGlass. It comes with a Windows server app that lets me browse my entire collection and stream them to my iPad one page at a time, without having to download anything.
When previewing (or occasionally reading) comics on my computer, I use MangaMeeya.
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