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I’d suggest trying an e-ink device first because reading experience is very similar to paper, although there is option to change the font size, of course. Perhaps a device with backlight is easier to your eyes, in such case there is the ebookwise and older reb1100, 1150 devices. I don’t think there is a global solution that fits all eye problems. For instance, I have keratoconus (eyesight at 15-20% without my contacts) but I can very well read paper (I think, it’s been years), e-ink or TFT (NOTE: with contacts my eyesight is near perfect 90%+ but I mean with naked eye).
As for the 12 different sizes, that isn’t the most flexible out there. Hanlin with Coolreader (and FBReader) supports total freedom, you specify font family/sizes for the different tags (<p>, <title>, <strong>, <emphasis> and so on), line height, text indent, margins, align etc; just like a web page.
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