Most PDF's are designed to be printed on 8.5"x11" paper.
The closer your e-screen is to that size, the easier the PDF will be to read.
Features like autocrop let you remove all the blank space around the edge of the page so that what is left can be expanded, hopefully closer to its original intended size without actually getting a bigger screen.
OCR and text reflow can be wonderful if they work, but they don't help at all when my page is one big diagram with embedded text, and are easily confused by multi-column text, especially when there are images and other irregularities between columns.
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