If you want to change your location to a different country, you also need to delete any saved credit card first. While it may be easier and quicker to have multiple accounts registered in other countries, it also means that you'll need to side load all the books purchased on secondary accounts.
As to whether it's cheaper to buy content from a foreign country, it generally depends on whether it's sold by a different publisher and whether there are any sales going on with the publisher. I know I've seen books be free or 90% off the price at a foreign country, so it certainly can be worth gaming the system. I also advise using a credit card that doesn't charge foreign transaction fees, these fees can add several dollars to the cost of a purchase.
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