I believe that media queries will or won't work depending on what you're asking for. For instance, if you ask for use of an SVG image, that won't work, because KFX doesn't yet support it. So, that could be used to avoid Enhanced Typesetting.
Or at least, it could before. KFX and Enhanced Typesetting are continually under development, so anything that's not supported at the moment could be supported at any time. And here's the rub: Previewer may not exactly reflect what's done to your file at Amazon. I have found formatting differences between the current Previewer Beta and newly published books with Enhanced Typesetting.
I think it's fruitless to try to pin down Enhanced Typesetting to create complex typography. Whatever you're doing could stop working tomorrow, and you might never know. If you need that kind of solidity, get the Kindle Textbook Creator and output fixed format.
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