What I'm saying is that <em> & <strong> is no different than using <span> with a class. In fact, <i> & <b> are also no different since you can change them via CSS.
In the example GrannyGrump gave, I've never seen any commercial eBook use <em> & <strong> for anything other than italics and bold. When text is being changed, it's done via a <span>.
Yes, I know some prefer to use <em> & <strong> and that's fine. But technically, no different.
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