I have the same issues. Started around January 2017. Spinning busy at almost every click action. I have about 10 libraries with 8-9,000 books. ThinkServer running latest Win10. Tried both 32 and 64 versions, no avail. Will try to find that list on conflicts.
Update 3/9 - I thought about any new installs I made the last couple months and identified the conflict as the StickyPasswords program. It maintains, generates and autofills logins, passwords, and forms. Luckily it allows for a list of programs to ignore and after entering calibre.exe the problems ceased.
Last edited by tjavatarici; 03-06-2017 at 09:08 AM.
Reason: Update information
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