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Please double check that just opening Acrobat has no impact on your permissions in your user temp area (not just the temp area used by acrobat) and the permsioons of Sigil own temp folder and its contents.
Please do the same for Sandboxie.
When the next error happens, please check permissions on the temp area and Sigil's specific temp folder and all its contents to rule out permissions completely, as some poorly written apps seem to force inhertance of permissions on subdirectories of the main temp directory.
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