[GrannyGrump]

@jswolfe --- not a real-world example in the sense you mean, but I have created experimental projects where I set the <em> to be Large Red font, instead of *italic, and <strong> to Large BLUE font instead of *bold*.

As chaot and BetterRed noted about semantics earlier in the thread, I have started using <i> and <b> for things such as foreign language, book titles, and such. Then I want the <em> and <strong> when showing, for example, someone shouting their dialog. This is really more for ease of editing the code, rather than concern about TTS, although that does enter into it a bit (can't hurt, might help).