If you like how portable the Sony PRS350 is, then definitely go for the Glo HD. Most of the 6" readers these days are only a centimetre or two bigger than the 350. There is a difference going from a non-lighted reader like the PRS350 to a lighted reader like the Glo HD, and not everyone loves the way it affects the screen, but they pretty much all have lights included now.
My reader of choice is now my Kindle Voyage (I've no interest in the anything bigger than 6", they seem too big to me), and as much as I still love my old PRS350, I can't go back to reading on it after the clarity of the screen on the Voyage.
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