This is an old thread but I though people would be interested. I have almost 230,000 books in my library and it runs like a rock. With this many books and as many directories (more than 40,000) that are in the root of the calibre library directory performance was big issue starting at about 100,000 books. I moved the library to it's own dedicated ssd on a sata3 interface and now the largest lag is 4 or 5 seconds instead of 30 seconds to a minute on search queries. It also helps that it is a 2.5 ghz i7 with 32 gigs or ram. I just checked and on a linux system with calibre running since a reboot yesterday it is using 5 gig's of memory on its own.
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