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I am not understanding your logic here. Having more than one version of the same book and pricing them differently should be avoided if you possibly can. When customers search for your book on Amazon or iTunes and multiple versions of the same come up that is going to create confusion and discourage sales.
If your book can be expressed at all reasonably in reflowable layout then that should be your choice for the best customer experience over a wide range of device types. It adapts to various screen sizes and allows the customer to select the font and font size most readable to them.
Only consider fixed layout for certain specific book types that can't be done well reflowable. Amazon limits fixed layout to children's books, comics/manga, and text books. The Kindle reading software has enhancements to support these book types, such as pop-up panels for comics. All other books should be reflowable on that platform.
How would a customer know whether to choose EPUB 2 or 3 when buying a book? Almost all of the differences between these formats are invisible to the customer. EPUB 3 with the proper EPUB 2 fall-backs should work just about anywhere. It won't matter on Amazon because your book will be converted to their propriety formats as part of the publishing process. I don't think it makes any difference on iTunes either.
The only exception I think makes sense is if you want a separate version with animation and/or audio (not narration) then do a different edition for that because the device support will be more limited and many customers will want to choose whether or not to have that feature.
Just my 2 cents.
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