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kiwik -
Added - I suggested portable because it is the 32bit variant of calibre, not because of it's portability. I've had driver/codec related BSODs (on Win 7 and 10) with two 64bit application programs. The 32bit versions work fine. The application vendors don't supply the drivers, they come from component hardware suppliers.
If portable continues to work you could try the regular 32 bit installed variant. That will use your existing libraries and preference settings

- BR