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It's quite possible to do manually, but that is extremely labor intensive. It would involve opening the ePub in an appropriate editor (e.g. Calibre ebook-editor or Sigil) and opening the RTF in a wordprocessor and then manually correcting the ePub using the RTF for reference.
It would be vastly easier to convert the RTF to ePub and then use an ePub editor to reformat the conversion to fit your taste.
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