Not happening here either.
I suspect its a 3rd party program that runs in the background, they often update themselves with you even knowing about it <grhhh>. So try disabling everything in Windows startup and rebooting. Also try running calibre after a minimal Safe Boot with no network.
Tip - rather than clicking on a cell to edit it, try using F2. And have a look at the different options for Preferences->Tweaks->Control behaviour of the book list->doubleclick_on_library_view. I have it set to 'do_nothing'.
BR
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