I avoid sub-full-page images wherever I can. The older Kindles don't handle them well, and few e-readers are large enough to display photo layouts. I generally upload images 800 pixels wide and use a width="100%" instruction so images don't look tiny on an iPad or a Fire 8.9 tablet.
The epub looks good on the Nook, though on B&N's version of Look Inside (not in the downloaded book) the cover is sometimes truncated. The cover was generated by Sigil from the product image, so perhaps I should resize that in the future to 800 pixels wide.
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