The 2 biggest complaints are the "natural light" colouring isn't as even as it should be and some people still having battery drain issues. The normal white light is about as even as it gets IMO, but the natural light still needs work and can be blotchy. If the natural light is your decider it might be a deal breaker. A firmware update seems to have solved battery drain issues for most people, so in theory that's not a big issue anymore.
There may be some problems with the official sleep cover either not properly putting it to sleep and/or turning pages when the cover is closed before it sleeps.
Touch responsiveness is a little slow (primarily in menus), possibly due to the larger screen size requiring more processing to update it.
Really depends on your personal use whether any of these things will bother you. For me the bigger screen size has trumped the rest. I find it hard to even go back to the H2O.
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