I've had several devices with IR touch screens (Sony PRS-350, PRS-650, Kobo Aura HD) and haven't had any problems using them. I do use the dictionary quite a bit with each of them, but don't use the highlighting feature.
I also have a couple capacitive screen devices (Kindle PW2 and Voyage), and for my use I really don't notice a difference--except when reading outside and as induna mentioned the occasional bug lands on the IR screen and turns the page for me.
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