"The song "Highway 61 Revisited," the title track from the album released in August 1965 — what do we know from this period in terms of his style?
Well, it's the Book of Genesis, right? It's the story of Abraham and Isaac and he's turning it into something that's very, very new. He's talking about Highway 61 ... a highway that runs right through the middle of America, all the way from Minnesota down to the Deep South. So, starting with the Bible. You know, this terrifying story of Abraham — who happens to be his father's name too, so when he's talking about "God said to Abraham, 'Kill me a son,'" yikes, it gets a little personal maybe, too. But he is telling a whole song about what's going on in America in his time through the idiom of the Bible. Rock 'n' roll, folk, it's all there."
http://www.npr.org/2016/10/13/497849...rary-alchemist