I haven't used the Nook S2 but I have used Galaxy Tabs. I used Moon+ reader with them, which I like a lot, and they worked very well. I'd give it a try. There's a free version that'll give you a nice feel for how it works and if you like it there's a Pro version for about $5 that adds a lot of extra features. The free version has all the features you'll need to see if it works on the Nook S2.
I'm not saying this is the best ereader, only that it's a good one and it's my preference.
Barry
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