@Hitch: IMHO, the best format for Bob's purposes would be the Kindle Print Replica textbook format, i.e., an Amazon DRM-wrapped PDF file.
However, AFAIK, you can't publish Kindle Print Replica books via Amazon KDP. (AFAIK, Amazon CreateSpace will accept .pdf files, but only for print-on-demand books.)
Have you ever prepared a Kindle Print Replica textbook for a "well-known educational publisher" or have you ever heard of someone who managed to sell a CreateSpace print-on-demand book as a Kindle Print Replica textbook?
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