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Honestly, for a productive setup, I don't think an epaper screen is the right choice at the moment From my experience the artifacts an epaper screen generates when the screen content changes (e.g. moving mouse cursor) can make the experience even more stressful for the eyes. I've since given up on trying to use an epaper screen as a monitor. The tech is too slow, requires too much fiddling and is too limited for a productive setup.
The only thing which would work well with an epaper screen is displaying static content. Content you want to read but don't interact with. But even then the switching between an LCD monitor and an epaper screen can be tiresome if their backlights don't match.
Maybe you should look for a different LCD monitor. I find that the panel and if the backlight is PWM controlled or not matter quite much for a comfortable experience. Another thing which could reduce eyestrain is to use a tool (e.g. f.lux or redshift) which sets the color temperature to the same temperature the sunlight has at a given point in time.
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