I'm going to pipe in for the Sony Reader. The Sony Reader has in AdobeDE the most advanced renderer of any device on the market right now. If most of your books are in formats other than Mobipocket, then you'll get the highest quality results on the Reader. Especially if many of your books are in LIT format, which it is very easy to convert essentially flawlessly to EPUB.
If you care about formatting quality, avoid primarily-Mobipocket devices. There are several threads here discussing the quite severe limitations of the format.
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