Restarting your computer by turning it off and on again seems to refresh it. I don't have lots of background programs but I've noticed that if I just hibernate or put the computer to sleep overnight and do this for several weeks it develops problems: becomes sluggish etc.
I'm no expert, but have been told that leaving your computer on and not doing much risks spybots (whatever they are) taking over your computer.
Personally, saving any necessay data then just closing down the browser and computer isn't a hassle. The next day when I open the browser I have the option to restore all the tabs I closed (on shutting down the browser) the day before. Simples!
Saves power too.
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