A failed backup usually means the database is corrupt. The process is to copy the database file and then run a check on it. If there are errors doing the check, then the file is renamed with the word "CORRUPT" in it.
I occasionally see other problems. They usually look like locked file issues, but by the time I can investigate, the problem has gone away. I don't know if it is the database that was locked or something else.
After error doing the backup, I recommend running a check on the database. This is part of the utilities plugin. If there are errors, some can be fixed by doing a compress. But, generally, I recommend restoring the last good backup. How well that works depends on how recent that last good backup is.
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