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Just adding my experience which is that I have had the H2O since launch and have had no trouble with connecting/disconnecting (from within Calibre) from either my iMac or MBP, both running 10.10.5 and using whichever USB cable I have lying around at the time. I know this doesn't help with your problem, and I hope you discover the reason and solution soon as it must be very annoying.
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