There may be many reasons why USB-devices stop working.
Windows keeps a list of every device that ever connected to the computer, to which port, which driver it used, and (if applicable) which drive letter it had.
I once helped a music store owner to sort out his laptop because no USB-device was working anymore. I found out that he had hundreds and hundreds of entries in the list, with many messed up drivers, because over the years, he had hundreds of piano's, keyboards and organs connected to that laptop for things such as firmware updates.
I removed every device driver that had anything to do with USB (including the mouse), and cleared the list. After rebooting the laptop, everything worked again (after driver re-install, where necessary).
The list can be viewed and cleared with
USBDeView by NirSoft. It can diagnose and fix many problems/conflicts by removing problematic drivers and entries.
Use this at your own risk.