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This looks like ADE is doing some kind of resampling without, or with minimal, interpolation (for speed I guess). If you want to keep the sharp edges and dots, there is nothing you can really do to improve display in ADE other than include a smaller image that won't have to be resized.
In general, you would want to filter out the high frequency components (like pdurrant did) but this will strip away the "noisy" detail that you want.
Given that you are selling from iTunes, presumably most readers will read in iBooks, so why do you care about ADE?
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