Yes, and I love it.
The CSS I added:
Code:
body {
font-variant-numeric: oldstyle-nums;
-moz-font-feature-settings:"liga=1, dlig=1";
-moz-font-feature-settings:"liga", "dlig"; /* EDIT: new syntax for FF 15+ */
-ms-font-feature-settings:"liga", "dlig";
-o-font-feature-settings:"liga", "dlig";
-webkit-font-feature-settings:"liga", "dlig";
font-feature-settings:"liga", "dlig";
}
I didn't yet remove the unneeded lines like for moz or see what was the minimum required. I'm not much of a programmer but had tried to make a basic ePub reader for OS X without getting very far. There's a Swift FolioReaderKit iOS reader on Github from which I did a similar CSS injection so seems possible, though for other style changes, you're probably already doing that.