Small files also make it easier to have a consistent chapter break formatting. If you have several chapters in the same file, breaks within the file may end up being rendered differently from breaks from file to file. If you can keep full "groups" within each file (like parts of a book, or books of a trilogy), it may not matter but then you are also more likely to hit some memory limit in some reader, and be forced to break the file at unnatural places anyway.
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