I find I rarely agree with Mike Perry, including this time. I almost never use the "use publisher settings" option on my reader. Either I have an issue with the fonts, the publisher's layout assumes a font size I don't like, the margins are atrocious or some other reason causes me to flip back to my preferred ereader settings. Perhaps if I were reading works with a lot of embedded illustrations or something with a lot of special fonts (for example, if China Mieville's Embassytown had used specially created fonts), I might want to use the publisher's settings, but that's about it. The fact of the matter is that you can't create an epub that looks uniformly great on all readers. Color, greyscale, margins, etc, all come into play and as someone else said, no design is going to please everyone. Should you even try? YES! But don't do it by creating wonky html and CSS that makes it fail on just about every reader but your favorite one. Make it easy for me to override your font, font size and margins. Oh, and feel free to fix those typos, grammatical errors and glaring plot holes while you're at it!
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