@
vinieux - try this
- Sign on to an admin account if you're not already,
- Take a Restore Point,
- Turn UAC off, if its on,
- In regedit find all references to calibre, delete them,
- Have a look in your AppData/Roaming/ directory for a directory called calibre, if found delete it,
- Have a look in the Program Files and Program Files (X86) (just in case) for a directory named Calbre2 , if found delete it,
- Restore UAC if you disabled it,
- Logon to normal account if necessary.
If anything goes horribly wrong do a System Restore.
Now see if the calibre you have on your portable drive works on the new laptop.
If it does work and if you want to migrate it to an installed calibre then I suggest you post a directory tree of what on your portable drive. Because, as theducks last posted, what you've told us thus far doesn't conform to calibre's 'standard structures'.
If it doesn't work then post the directory tree.

Afterthought - what version of calibre is on the portable drive and what's it provenance - i.e. where and when did you get it?
BR