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Sigh, how many times do I need to repeat this. calibre does not associate itself with *any* file types. It only tells windows what filetypes it is *capable* of handling.
And as for IrfanView, it will be creating system wide file associations -- a practice that Microsoft themselves say applications should not do.
Finally, you do not need to run it every time, only if you decide to switch between 32 bit installs and 64 bit installs, though why you would do so, more than once, I haven't the foggiest.
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