Not all epubs are the same in this regard. Fortunately, KOReader has settings to work around the formatting and fonts that the publisher applies to their ebook. While they can use formatting commands to prevent their settings from being changed, Koreader can ignore or remove the style sheet settings in the ebook. Then even books that try to prevent such changes can be changed by the KOReader settings.
The first to try is the "Embedded style" option under the bottom reader menu gear icon/tab. If turning that off doesn't let you change the font, you can try the "Set render style" > "clear all external styles" option. You might have to reload the book or restart KOReader to see the effect of the changes you make. For fonts, I have had to change the size to see the change, sometimes.
Luck;
Ken
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