@mobamoba: things update all the time all by themselves. For example your AV probably updates daily. Windows updates monthly. You have almost certainly updated other software on the machine.
Calibre restart does in fact change the firewall. It notices that the program is no longer running and changes its internal rule set. The same thing is true for the AV.
If you want to say that nothing changed so the problem must be elsewhere, then we can say the same thing between connections. Nothing at all changed in CC or calibre between those connections, so whatever is blocking the connection must be external to them. Now, I don't really believe that, but it is the same argument you are making.
I hope that the debug logs say something interesting.
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