I will bite.

Why?
Modern devices (>2009) will greyscale (display) a color image just fine.
I can not believe a 16 bit Greyscale will save that much filesize over the same size color image.
Preferences: (to set system FIRST TIME Conversion default)
Conversion: (to control or override defaults for the current book only)
Common Options: Page setup: Output Profile (hover over device model for details)