Quote:
Originally Posted by Purple Lady
I guess the simplest suggestion is the best! I renamed the folder and it came right up. Thanks! 
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You're welcome
The .NET-error threw me off, thinking it was a problem with ADE. I should have thought of renaming the folder as the first suggestion. Removing plugins, data-files, profiles, and non-essential configuration files from a program is always the first thing to do if it suddenly stops working.
You might need to redownload books you had in the ADE folder if you want to read them or transfer them to an e-reader. I don't know; I never keep them there. After importing and unDRM-ing in calibre, I remove them from ADE and the "My Digital Editions" folder.