Well I opened a doc in Wordpad and with Calibre opened I tried to save the changes I made and it pretty much told me I couldn't because the file was being used elsewhere. Again, this hadn't happened before...but I suppose it makes sense.
I think I'm going to have to hunt down an older version of Calibre because I didn't realize just how frustrating it is to have to shut the program down just to save minor fixes to html code and re-upload.