I haven't tried it on the iPad, but I use f.lux all day on my Mac -- because my eyes seem to be really sensitive to working all day at a computer screen. The dimmed screen (oranged, I guess, really) causes less squinting by the end of the day.
Note that I have to FOOL f.lux into thinking it is night-time during my daytime shift. But that's no big deal, for f.lux. If the iPad uses the REAL clock, then one wouldn't be able to get this effect at other times of the day. And that would be less worthwhile, for me!
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