I nominate The Apothecary Rose (Owen Archer, #1) by Candace Robb
https://www.goodreads.com/series/41413-owen-archer
Quote:
The Owen Archer mysteries (including the short story "The Bone Jar" ) are set in England in the late 14th century. Owen Archer is a spy for John Thoresby, Archbishop of York and sometime Lord Chancellor of England. Owen is ably assisted in his sleuthing by an ensemble of York residents who include his wife, the Apothecary Lucie Wilton; Bess Merchet, proprietor of the York Tavern; Magda Digby, midwife; and Brother Michaelo, the Archbishop's secretary.
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