People's responses on "the best" screen to avoid eyestrain vary widely. I will state however that yours is the first report I've read of eyestrain while using an e-ink reader.
I will say however that the Kobos have the best range of options for customizing the text of an e-book. It may be that a change in size, line spacing, or even the font itself would help you. Or, if you go for the Glo HD, you may find that having a built in light is an improvement.
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