Quote:
Originally Posted by eschwartz
calibre uses an SSL certificate bundled into the update script, and based on the posted error it successfully downloaded the installer script from github but errored in get_https_resource_securely trying to download the signature from calibre's website.
I've seen this problem before I believe  sometimes distros do stupid things to their python package.
Try extracting the tarball manually, see the note about manual installs at the bottom of the download page.
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Manually installed, everything worked fine. Running 2.46 now.
One other thing which may have caused this is the update from CentOS7 to 7.2 yesterday.
Anyway, I am fine now and know, what to do if something like this happens again.

Thanks you all for your help.