Congratulations! You are the 1,000,000th person to ask this question!
Your prize is your very own hyperlink to the sticky on this very topic!
https://www.mobileread.com/forums/sho...d.php?t=119175
Okay, okay, I apologize for having fun at your expense. You may not be the 1,000,000th person to ask this question, but you're probably close.
In all seriousness, the short answer is: No, you can't do this. The long answer is: If you're looking at the files themselves, you're doing something wrong.
Pretend those files don't exist. Pretend they're locked up inside a magical black box that you can't see into. Now, with this assumption, figure out how to use Calibre to do what you want. Chances are, you'll come up with a new work flow that's as easy as, or possibly even easier than, what you've been doing before.