Well, I usually start from the front, and read towards the back. I think this method provides the best story experience. I prefer black letters on a white background, though at night, when my wife is sleeping, I will go crazy and use white letters on a black background. I figure, what she doesn't know, won't hurt her. And as a native English speaker, I find books in English to be the easiest books to read.
Hope this helps.
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