Quote:
Originally Posted by pdurrant
#1.
Write it without the clause and there's no problem:
Her vulnerability had led her to kill another human being.
To add the clause, you need to have both commas.
Her vulnerability, her inability to tolerate ridicule, had led her to kill another human being.
Although I would prefer a small change to
Her vulnerability, an inability to tolerate ridicule, had led her to kill another human being.
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Now yours has "an inability to tolerate ridicule" as an appositive phrase.
Interesting in that each tiny change makes a nuance change in meaning.