On one word titles:
I think it depends on genre.
I will use Wool as an example. When Wool originally came out, I was in a knitting forum. There was actually a thread devoted to that book. The reason being was because several knitters saw the title and immediately thought it related to the wool that comes from sheep. So they grabbed the book. Perhaps they should have read the blurb.
Oh note, this is Hugh Howey's Wool.
Now as to Dust, in the post-apocalyptic means one thing, in household, it would be totally different.
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